Intracytoplasmic Sperm Injection (ICSI) is a micromanipulation procedure involves the direct injection of a single sperm into an egg to attempt fertilization. It usually used with male infertility or patients with previous IVF failure. There are generally five simple steps are involved in ICSI procedure which include the following:
- The mature egg has been collected in a specialized glass tube.
- A hollow, very delicate and sharp needle is used to pick up and immobilize a single sperm.
- With care, the needle is then inserted through the cytoplasm of the egg and shell of the egg.
- The sperm is carefully injected into the cytoplasm and the needle is than removed.
- Following day, the eggs are checked further for the sign and evidence of normal fertilization.
The embryo transfer process is followed to physically plant the embryo in the woman’s uterus, once the all steps of ICSI are completed and fertilization become successful. Then it is a event to wait and watch for early pregnancy symptoms. The doctor may use ultrasound reports or a blood test to verify if implantation and pregnancy has occurred successfully.
Risks associated with ICSI
There are also several risks associated with ICSI procedure. The first risk is that, during the ICSI procedure, as a result of the needle insertion a small number of eggs (approximately less than 5 percent) may be damaged. Second, the overall risk of having a baby with a chromosomal abnormality in the X or Y chromosomes is 0.8 percent (or eight per 1000) which is nearly four times the average found with spontaneous conception. At present, we are unable to figure out the exact reason for this increased risk. It is important to know the following problems can be involved with sex chromosome abnormalities:
- There may be a requirement of surgery for affected infants with heart problems
- Increased risk of miscarriage
- Increased risk of learning disabilities or behavior abnormality
- Increased risk of serious infertility issues in your children during their adulthood
- The risk of having a chromosomal abnormality like Down’s syndrome is basically not increased with ICSI procedure but increases with maternal age.
If a successfully fertilization takes place, a women chance of giving birth to a single baby, twins, or triplets is the same if they have IVF with or without ICSI. Several studies have indicated the issue of developmental delays in children born with ICSI. But, there is no definitive proof that this is the case.
How successful is ICSI?
Chances of successful fertilization with this procedure vary between patients (particularly according to the age of the woman). Fertilization rates of nearly 80 percent of all eggs injected which is equivalent to fertilization with normal sperm are currently being achieved, and high pregnancy rates are seen with ICSI procedure for the couples suffering male factor infertility.
The most important indicator of ICSI success found to be the fertilization rate achieved during the ICSI procedure. The fertilization rate at SCI Healthcare and SCI IVF Hospital and Multi-specialty Center is exceptional high (currently 80 to 85 percent). This indicates, on average, eight out of every 10 eggs will fertilize in proper and normal way.